The Atrophy Arc
The Atrophy Arc, End to End
The four-part Atrophy Arc in one place. Every advance, from defining the lesion to slowing it, is a growing command over an anatomical endpoint, while the patient's vision stays out of frame.
The Atrophy Arc
The Atrophy Arc
What Slowing the Lesion Changes
The first approved treatment for geographic atrophy slows the lesion on OCT in OAKS and DERBY. Read closely: real, partial, and not yet shown to protect sight.
The Atrophy Arc
Which Early Sign Sees It Coming
iRORA names the stage before geographic atrophy, and consensus offered its progression as a trial measure. Followed over time, a different early OCT sign predicts progression better, and one two readers agree on more readily.
The Atrophy Arc
What Two Readers Can Agree On
A definition is only worth what two readers can independently reproduce. Classification of Atrophy Report 6 tested whether graders agree on the OCT signs of early atrophy, and the answer complicates the endpoint we just defined
The Atrophy Arc
What We Mean by Atrophy
The Atrophy Arc opens by defining its endpoint: cRORA, complete RPE and outer retinal atrophy, and the four consensus criteria that mark it on OCT